Emergency and Toxicologymiddle twist
A 63-year-old woman with acute myeloid leukaemia has had febrile neutropenia for 96 hours despite piperacillin-tazobactam. She remains haemodynamically stable, repeated blood cultures are negative and CT chest shows no focal lesion. Her absolute neutrophil count is 0.1 × 10⁹/L and recovery is not expected for at least another week. What additional treatment is most appropriate now?