Cardiovascularmiddle twist
A 59-year-old woman develops sharp central chest pain two days after an uncomplicated ST-elevation myocardial infarction. She says it is worse when she takes a deep breath or lies flat and improves when she sits forward; the ECG now shows widespread ST-segment elevation with PR-segment depression rather than changes confined to the infarct territory. Which one of the following is the most appropriate treatment?