A 7-year-old boy is brought in by his mother, who has biopsy-proven coeliac disease, as does his older sister.…

Question

A 7-year-old boy is brought in by his mother, who has biopsy-proven coeliac disease, as does his older sister. He is well, on the 50th centile for height and weight, and has no gastrointestinal symptoms. Six months ago the family removed all gluten from the household and he has eaten none since. His mother is adamant that she will not put gluten back into his diet, but wants to know whether he has the condition. Which one of the following investigations is most likely to give a useful answer wit…

Accepted Answer

HLA-DQ2 and DQ8 typing.

Answer

Faecal calprotectin.

Answer

Serum deamidated gliadin peptide IgG.

Answer

Serum tissue transglutaminase IgA.

Answer

Small bowel biopsy.

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