A 58-year-old man receiving induction chemotherapy for acute myeloid leukaemia presents with a temperature of 39.1°C. His absolute neutrophil count is 0.05 × 10⁹/L (reference range 2.0–7.5), blood pressure is 118/70 mmHg and examination does not identify a focal infection. He has no immediate penicillin allergy, recent resistant organism or haemodynamic instability. Which empiric antimicrobial treatment is most appropriate?
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