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A 34-year-old man is brought to the emergency department six hours after his general practitioner increased his sertraline and added tramadol for back pain. He was started on quetiapine for insomnia four days ago and last used methamphetamine three days ago. He is restless and shivering. Temperature 38.9 °C, heart rate 124/min in sinus rhythm, blood pressure 155/90 mmHg; no goitre is palpable. His shirt is soaked with sweat and bowel sounds are active. Passive dorsiflexion of both ankles produces several rhythmic beats, the knee jerks are brisker than the biceps jerks, and there is no rigidity. Which one of the following best explains his fever, agitation and reflex findings?
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