A 26-year-old woman weighing 60 kg presents five hours after swallowing an unknown number of immediate-release…

Question

A 26-year-old woman weighing 60 kg presents five hours after swallowing an unknown number of immediate-release paracetamol tablets. She is alert with normal observations and has vomited twice. The serum paracetamol concentration on the sample drawn four hours after ingestion is 2450 micromol/L. The alanine aminotransferase and the international normalised ratio are both normal. A decision has been made to start intravenous acetylcysteine now. Which one of the following acetylcysteine regimens sh…

Accepted Answer

200 mg/kg over 4 hours, then 200 mg/kg over 16 hours

Answer

100 mg/kg over 4 hours, then 200 mg/kg over 16 hours

Answer

150 mg/kg over 15 minutes, then 50 mg/kg over 4 hours

Answer

150 mg/kg over 60 minutes, then 100 mg/kg over 16 hours

Answer

200 mg/kg over 4 hours, then 100 mg/kg over 16 hours

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