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A 77-year-old woman is brought to the emergency department by her daughter because she has become confused and unsteady over three days. Five weeks ago her general practitioner started sertraline for a depressive episode; she takes no other medicines. She is afebrile and drowsy but rousable, with normal pupils, moist skin, audible bowel sounds and normal tone; there is no tremor, clonus or rigidity. Blood glucose is 6.1 mmol/L, sodium 118 mmol/L (135-145), potassium 4.0 mmol/L (3.5-5.2), creatinine 61 micromol/L (45-90) and creatine kinase 90 U/L (30-150). Which one of the following best accounts for her confusion?
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