Mechanisms of disease
How disease happens — pathology, pharmacology, microbiology. 13 questions.
A 30-hour-old boy develops jaundice and pallor. He is feeding reasonably well and has mild splenomegaly. His mother is blood group O positive and he is group B…
Paediatrics · Mechanisms of disease · middle twist
A 67-year-old man with alcohol dependence has mild withdrawal 10 hours after his last drink, with anxiety, tremor and nausea but no hallucinations or seizure. H…
Gastroenterology and Hepatology · Mechanisms of disease · middle twist
A 59-year-old woman develops sharp central chest pain two days after an uncomplicated ST-elevation myocardial infarction. She says it is worse when she takes a…
Cardiovascular · Mechanisms of disease · middle twist
A 29-year-old woman requests emergency contraception four days after unprotected intercourse. She has a body mass index of 34 kg/m² and takes carbamazepine for…
Obstetrics and Gynaecology · Mechanisms of disease · middle twist
A 54-year-old woman has progressive exertional dyspnoea. Spirometry shows a forced expiratory volume in one second of 2.4 L (reference greater than 2.0 L) and a…
Biomedical Science · Mechanisms of disease · middle twist
A 41-year-old woman has progressive weight gain, proximal muscle weakness and easy bruising. Her 24-hour urinary free cortisol is 780 nmol/day (reference less t…
Biomedical Science · Mechanisms of disease · middle twist
A 29-year-old woman has a plasma bicarbonate concentration of 15 mmol/L (reference 22–29 mmol/L) and a normal anion gap. Her urine pH is 6.2 during bicarbonate…
Biomedical Science · Mechanisms of disease · middle twist
A 21-year-old woman presents to the GP with urinary urgency, suprapubic discomfort, and dysuria. This is her third similar episode in the past year. She does no…
Year 1 · Mechanisms of disease · middle twist
A 45-year-old woman with diabetes mellitus presents with a painful, rapidly expanding area of redness on her thigh. She has a fever of 39°C (102.2°F) and hypote…
Year 1 · Mechanisms of disease · middle twist
A 65-year-old man presents with purple spots on his forearms and hands that appeared over the past few days. He denies pain, itching, or trauma. His medical his…
Year 1 · Mechanisms of disease · middle twist
During an epidemiological study of a population of 100,500 people, 500 individuals were identified as existing cases of a certain disease. Over the course of on…
Year 4 · Mechanisms of disease · middle twist
You are conducting a routine developmental assessment on Leo, a healthy 8-week-old infant who was born full-term. His parents are curious about his developmenta…
Year 3 · Mechanisms of disease · middle twist
A 25-year-old patient receiving acetylcysteine for immediate-release paracetamol poisoning develops a rash, urticaria, and flushing shortly after the infusion s…
Curtin CAT · Mechanisms of disease · middle twist