Platelet and vascular wall disorders

A 4-year-old boy develops widespread bruising on his shins and trunk and a crop of pinpoint red spots on his legs over three days, two weeks after a cold. He is…

Clinical rotations · middle twist

A 66-year-old woman is on day 8 after an elective total hip replacement and has been receiving subcutaneous enoxaparin 40 mg daily since surgery. Her platelet c…

Pre-internship · niche

A 29-year-old woman presents with headache, confusion and reduced urine output. She is pale and has scattered petechiae; investigations show haemoglobin 78 g/L…

Clinical rotations · middle twist

A 58-year-old man is being treated with unfractionated heparin for a proximal deep vein thrombosis. On day 7, his platelet count has fallen from 224 to 86 × 10⁹…

Clinical rotations · common

A 65-year-old man presents with purple spots on his forearms and hands that appeared over the past few days. He denies pain, itching, or trauma. His medical his…

Mechanisms of disease · middle twist