Prostate cancer practice

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EverythingAMC examMedical schoolNursingBiomedical science

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Any stageFoundations71Mechanisms of disease35Clinical rotations832Pre-internship488

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AnyCommon535Middle twist776Niche but important115

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Year 4middle twist
A 54-year-old man with no family history of prostate cancer attends his GP for a routine check-up. He is asymptomatic and has no significant past medical history. He asks about prostate cancer screening. After a discussion about the benefits and harms of prostate-specific antigen (PSA) testing, he decides to proceed. His initial total PSA result is 4.2 ng/mL (reference range: <3.0 ng/mL for further investigation). According to current guidelines, what is the most appropriate next diagnostic step?