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Middle twist

One twist — a threshold, a comorbidity, an atypical presentation. 741 questions.

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A 67-year-old man has recurrent sinusitis, otitis and a persistent cough with occasional blood-streaked sputum. Urinalysis shows dysmorphic red cells and red-ce…

Rheumatology and Musculoskeletal · Clinical rotations · middle twist

A 74-year-old woman has 3 weeks of a new unilateral temporal headache and pain in her jaw when chewing. She has no visual symptoms, limb weakness or constitutio…

Rheumatology and Musculoskeletal · Clinical rotations · middle twist

A 79-year-old man living in Western Australia has recently been diagnosed with a terminal lung disease. He lives alone, receives the age pension, and holds a va…

Year 1 · Foundations · middle twist

A 21-year-old woman presents to the GP with urinary urgency, suprapubic discomfort, and dysuria. This is her third similar episode in the past year. She does no…

Year 1 · Mechanisms of disease · middle twist

A 36-year-old man presents with 2 days of fever, nausea, abdominal cramps, and watery diarrhoea after returning from a trip to Bali. He ate street food and dran…

Year 1 · Foundations · middle twist

A 54-year-old man with no family history of prostate cancer attends his GP for a routine check-up. He is asymptomatic and has no significant past medical histor…

Year 4 · Clinical rotations · middle twist

A 58-year-old man with no symptoms attends your clinic for a general health check. He is concerned because his uncle and cousin both died of pancreatic cancer.…

Year 4 · Clinical rotations · middle twist

A 60-year-old man with a history of chronic diarrhea presents with muscle weakness and lethargy. Laboratory tests show: potassium 3.1 mmol/L (3.5-5.0 mmol/L), b…

Year 4 · Clinical rotations · middle twist

A 64-year-old man presents with a right-sided groin bulge that becomes more prominent on coughing. He reports no pain and has no difficulty with daily activitie…

Year 4 · Clinical rotations · middle twist

A 62-year-old man presents with a bulge in his right groin that becomes more prominent when he coughs and reduces spontaneously when lying down. On examination,…

Year 4 · Foundations · middle twist

A 54-year-old man presents with persistent heartburn and regurgitation despite six weeks of once-daily omeprazole. He has no dysphagia, weight loss, or anemia.…

Year 4 · Clinical rotations · middle twist

A 72-year-old woman is undergoing evaluation for persistent postprandial fullness and intermittent epigastric discomfort. She has no history of reflux or dyspha…

Year 4 · Clinical rotations · middle twist

A 58-year-old man with a 3-year history of gastroesophageal reflux disease (GERD) undergoes an upper endoscopy for ongoing reflux symptoms. Endoscopy reveals a…

Year 4 · Clinical rotations · middle twist

A 68-year-old man presents to his general practitioner for a routine review of his medications. He has a history of osteoarthritis, for which he takes naproxen…

Year 4 · Clinical rotations · middle twist

A 76-year-old man presents to the emergency department with a 6-hour history of passing large volumes of bright red blood per rectum. He feels lightheaded and f…

Year 4 · Clinical rotations · middle twist

A 68-year-old man presents to the emergency department with a 24-hour history of worsening abdominal pain, nausea, and vomiting. He has a history of open sigmoi…

Year 4 · Clinical rotations · middle twist

A 67-year-old man presents to the emergency department with a 2-day history of severe diarrhea, abdominal cramping, and fever (38.5°C). His symptoms began appro…

Year 1 · Foundations · middle twist

A 45-year-old woman with diabetes mellitus presents with a painful, rapidly expanding area of redness on her thigh. She has a fever of 39°C (102.2°F) and hypote…

Year 1 · Mechanisms of disease · middle twist

A 65-year-old man presents with purple spots on his forearms and hands that appeared over the past few days. He denies pain, itching, or trauma. His medical his…

Year 1 · Mechanisms of disease · middle twist

A histological sample from a region with high mechanical stress shows stratified squamous epithelium. Which of the following characteristics would distinguish w…

Year 1 · Foundations · middle twist