Haematology and Oncology

A 7-year-old boy has complained of pain in both thighs and an intermittent limp for one month. He is pale but afebrile, and there is no joint swelling; both hip…

A 26-year-old woman has painless enlargement of several cervical lymph nodes, night sweats and generalised itch. She has no recent dental infection, cat exposur…

A 46-year-old man develops jaundice, dark urine and exertional dyspnoea over several weeks. He has splenomegaly, a haemoglobin concentration of 78 g/L (130–170)…

A 58-year-old woman presents with tiredness, a sore tongue and difficulty judging the position of her feet in the dark. She has a macrocytic anaemia, a low seru…

A 41-year-old woman has been stable on clozapine for 18 months but presents with fever, painful swallowing and malaise. Her temperature is 38.5°C and her absolu…

A 24-year-old woman of Greek background is found to have abnormal results on a pre-employment blood count. She feels well, her periods are not heavy, and she re…

A 29-year-old woman has painless cervical and mediastinal lymphadenopathy that has progressed over 2 months. She reports drenching night sweats and pruritus but…

A 71-year-old man presents with headache, blurred vision and spontaneous bruising. Blood tests show haemoglobin 86 g/L (reference range 130–170), total protein…

A 58-year-old man receiving induction chemotherapy for acute myeloid leukaemia presents with a temperature of 39.1°C. His absolute neutrophil count is 0.05 × 10…

A 67-year-old woman develops a temperature of 38.3°C and rigors 30 minutes after a red-cell transfusion begins. She is haemodynamically stable and has no dyspno…

A 68-year-old man reports persistent thoracic back pain and fatigue for 3 months. His haemoglobin is 92 g/L (reference range 130–170), creatinine is 180 micromo…